Hydrochloric Acid → HCID 59848776, compound

HRID 599513Notes

Reaction equation

HRID 599513 reaction equation
[C:1]([C:3]1[C:4]([C:16]2[CH:38]=[CH:37][C:19]([C:20]([NH:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[NH:29]C(=O)OC(C)(C)C)=[O:21])=[CH:18][CH:17]=2)=[N:5][CH:6]=[C:7]([CH2:9][O:10][CH2:11][CH2:12][NH:13][CH2:14][CH3:15])[CH:8]=1)#[N:2].Cl>O1CCOCC1>[NH2:29][C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=1[NH:22][C:20](=[O:21])[C:19]1[CH:37]=[CH:38][C:16]([C:4]2[C:3]([C:1]#[N:2])=[CH:8][C:7]([CH2:9][O:10][CH2:11][CH2:12][NH:13][CH2:14][CH3:15])=[CH:6][N:5]=2)=[CH:17][CH:18]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59848804HCID 59848804, compound

Product 1

HCID 59848776HCID 59848776, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

t-Butyl (2-{[4-(3-cyano-5-{[2-(ethylamino)ethoxy]methyl}pyridin-2-yl)benzoyl]amino}phenyl)carbamate (466 mg, 0.90 mmol, prepared as described in Method 28), 1,4-dioxane (3.4 ml) and a 4M solution of hydrogen chloride in 1,4-dioxane (3.4 ml) were stirred at ambient temperature for 4 hours.

Sources & evidence

ORD record
ord-9c86df57d0164f6bb4e4e628cad587d0
Source dataset
uspto-grants-2011_03
Patent number
US07897778B2

Reaction notes

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