Hydrochloric Acid → HCID 59848735, compound

HRID 599515Notes

Reaction equation

HRID 599515 reaction equation
[C:1]([C:3]1[C:4]([C:17]2[CH:39]=[CH:38][C:20]([C:21]([NH:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[NH:30]C(=O)OC(C)(C)C)=[O:22])=[CH:19][CH:18]=2)=[N:5][CH:6]=[C:7]([CH2:9][O:10][CH2:11][CH2:12][NH:13][CH:14]([CH3:16])[CH3:15])[CH:8]=1)#[N:2].Cl>O1CCOCC1>[NH2:30][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=1[NH:23][C:21](=[O:22])[C:20]1[CH:38]=[CH:39][C:17]([C:4]2[C:3]([C:1]#[N:2])=[CH:8][C:7]([CH2:9][O:10][CH2:11][CH2:12][NH:13][CH:14]([CH3:15])[CH3:16])=[CH:6][N:5]=2)=[CH:18][CH:19]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59848780HCID 59848780, compound

Product 1

HCID 59848735HCID 59848735, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

t-Butyl (2-{[4-(3-cyano-5-{[2-(isopropylamino)ethoxy]methyl}pyridin-2-yl)benzoyl]amino}phenyl)carbamate (170 mg, 0.32 mmol, prepared as described in Method 31), 1,4-dioxane (1.5 ml) and a 4M solution of hydrogen chloride in 1,4-dioxane (1.2 ml) were stirred at ambient temperature for 21 hours.

Sources & evidence

ORD record
ord-d767a368d0324ec1afaed70230ef1ed8
Source dataset
uspto-grants-2011_03
Patent number
US07897778B2

Reaction notes

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