Ammonium Hydroxide → HCID 178513742, compound

HRID 59955Notes

Reaction equation

HRID 59955 reaction equation
[OH:1][C:2]1[C:3]2[CH:11]=[N:10][CH:9]=[C:8]([C:12]([O:14]C)=O)[C:4]=2[N:5]=[CH:6][N:7]=1.[NH4+:16].[OH-]>CO>[OH:1][C:2]1[C:3]2[CH:11]=[N:10][CH:9]=[C:8]([C:12]([NH2:16])=[O:14])[C:4]=2[N:5]=[CH:6][N:7]=1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 178498783HCID 178498783, compound

Product 1

HCID 178513742HCID 178513742, compoundYield 41.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The mixture of methyl 4-hydroxypyrido[4,3-d]pyrimidine-8-carboxylate (47 mg, 0.1 mmol), NH4OH (3 mL) and MeOH (10 mL) was heated to reflux for 20 hours in a sealed tube. The mixture was then concentrated and purified by prep-HPLC to afford the title compound as a white solid (yield 41.1%).

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 20 hours in a sealed tube
  3. concentrationThe mixture was then concentrated
  4. custompurified by prep-HPLC

Sources & evidence

ORD record
ord-1832a42924764ce6af2fccc537584134
Source dataset
uspto-grants-2016_09
Patent number
US09440968B2

Reaction notes

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