反应详情

The mixture of methyl 4-hydroxypyrido[4,3-d]pyrimidine-8-carboxylate (47 mg, 0.1 mmol), NH4OH (3 mL) and MeOH (10 mL) was heated to reflux for 20 hours in a sealed tube. The mixture was then concentrated and purified by prep-HPLC to afford the title compound as a white solid (yield 41.1%).

1. temperaturewas heated
2. temperatureto reflux for 20 hours in a sealed tube
3. concentrationThe mixture was then concentrated
4. custompurified by prep-HPLC