Diethyl Ether → (S)-2-phenylpropionic acid hydrazide monohydrochloride

HRID 599607Notes

Reaction equation

HRID 599607 reaction equation
C(OCC)(=O)C.[ClH:7].[C:8]1([C@H:14]([CH3:26])[C:15]([NH:17][NH:18]C(OC(C)(C)C)=O)=[O:16])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.C(OCC)C>C(OCC)(=O)C>[ClH:7].[C:8]1([C@H:14]([CH3:26])[C:15]([NH:17][NH2:18])=[O:16])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 21866389Hydrogen chloride-ethyl acetateHCID 67067040HCID 67067040, compound

Product 1

HCID 67067272(S)-2-phenylpropionic acid hydrazide monohydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4 N hydrogen chloride-ethyl acetate (2 mL) was added to a suspension of tert-butyl N′-((S)-2-phenylpropionyl)hydrazinecarboxylate (470 mg) in ethyl acetate (4 mL), and the reaction solution was stirred at room temperature overnight. Diethyl ether (6 mL) was added to the reaction solution, and the precipitated powder was collected by filtration. The resulting solid was dried under reduced pressure to obtain 280 mg of the title compound. The property values of the compound are as follows.

Workup

  1. filtrationthe precipitated powder was collected by filtration
  2. customThe resulting solid was dried under reduced pressure

Sources & evidence

ORD record
ord-41e40c4ab0304f899b4160be07393244
Source dataset
uspto-grants-2011_03
Patent number
US07897632B2

Reaction notes

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