Ethyl Acetate → HCID 67067396, compound

HRID 599621Notes

Reaction equation

HRID 599621 reaction equation
[NH2:1][NH2:2].[Cl:3][CH2:4][CH2:5][CH2:6][C:7]([C:19]#[N:20])([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:8](OCC)=[O:9].C(OCC)(=O)C.O.C(=O)(O)[O-].[Na+]>C(O)C>[Cl:3][CH2:4][CH2:5][CH2:6][C:7]([C:19]#[N:20])([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:8]([NH:1][NH2:2])=[O:9]

Participants

6

Reactant 4

HCID 8857Ethyl AcetateHCID 9321HydrazineHCID 67067289HCID 67067289, compoundHCID 86585896Sodium bicarbonate water

Product 1

HCID 67067396HCID 67067396, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Hydrazine (1.2 g) was added to a solution of ethyl 5-chloro-2-cyano-2-phenylpentanoate (CAS No. 52370-87-3, 1 g) in ethanol (5 mL), and the reaction solution was stirred at room temperature for one hour. Ethyl acetate and saturated sodium bicarbonate water were added to the reaction solution, and the organic layer was separated. The resulting organic layer was filtered through a silica gel, and the filtrate was concentrated under reduced pressure to obtain a crude product of 5-chloro-2-cyano-2-phenylpentanoic acid hydrazide.

Workup

  1. customthe organic layer was separated
  2. filtrationThe resulting organic layer was filtered through a silica gel
  3. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-d88c0468c4684af18865edd45873edb5
Source dataset
uspto-grants-2011_03
Patent number
US07897632B2

Reaction notes

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