反应详情

A suspension of 2.1 (5.87 mmol) 1′-benzyl-4-methoxy-[1,4′]bipiperidinyl and 1.0 g 10% Pd/C in 50 mL MeOH and 20 mL water was hydrogenated for 8 h at RT and 3 bar hydrogen pressure. The catalyst was removed by suction filtering, the filtrate was concentrated by evaporation i.vac., the residue was triturated with diethyl ether, suction filtered and dried.

1. customThe catalyst was removed by suction
2. filtrationfiltering
3. concentrationthe filtrate was concentrated by evaporation i.vac
4. custom, the residue was triturated with diethyl ether, suction
5. filtrationfiltered
6. customdried