HuagongsheHuagongshe Chemistry Print Report · For research reference only
1'-Benzyl-4-methoxy-[1,4']bipiperidinyl → 4-Methoxy-1,4'-bipiperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1'-Benzyl-4-methoxy-[1,4']bipiperidinyl | HCID 67273809 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Methoxy-1,4'-bipiperidine | HCID 43373003 | — |
Reaction Steps
A suspension of 2.1 (5.87 mmol) 1′-benzyl-4-methoxy-[1,4′]bipiperidinyl and 1.0 g 10% Pd/C in 50 mL MeOH and 20 mL water was hydrogenated for 8 h at RT and 3 bar hydrogen pressure. The catalyst was removed by suction filtering, the filtrate was concentrated by evaporation i.vac., the residue was triturated with diethyl ether, suction filtered and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07897603B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-30e6a671dd71497591c6d2cf0e0560c0 |
| Source note | uspto-grants-2011_03 |