Morpholine → 1-Benzyl-4-morpholinopiperidine-4-carbonitrile

HRID 599731Notes

Reaction equation

HRID 599731 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11](O)([C:14]#[N:15])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:17]1[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1>CO>[CH2:1]([N:8]1[CH2:13][CH2:12][C:11]([N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)([C:14]#[N:15])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 801891-Benzyl-4-hydroxypiperidine-4-carbonitrile

Product 1

HCID 227417611-Benzyl-4-morpholinopiperidine-4-carbonitrile

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 5.25 g (23.8 mmol) 1-benzyl-4-hydroxy-piperidine-4-carbonitrile and 2.2 mL (25.2 mmol) morpholine in 30 mL MeOH was refluxed for 6 h. The mixture was evaporated to dryness i.vac., while the product was obtained in the form of crystals.

Workup

  1. customThe mixture was evaporated to dryness i.vac
  2. custom, while the product was obtained in the form of crystals

Sources & evidence

ORD record
ord-ff3233e750fb431f84f96d39c4cb6b6d
Source dataset
uspto-grants-2011_03
Patent number
US07897603B2

Reaction notes

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