HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → 1-Benzyl-4-morpholinopiperidine-4-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 1-Benzyl-4-hydroxypiperidine-4-carbonitrile | HCID 80189 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-Benzyl-4-morpholinopiperidine-4-carbonitrile | HCID 22741761 | — |
Reaction Steps
A solution of 5.25 g (23.8 mmol) 1-benzyl-4-hydroxy-piperidine-4-carbonitrile and 2.2 mL (25.2 mmol) morpholine in 30 mL MeOH was refluxed for 6 h. The mixture was evaporated to dryness i.vac., while the product was obtained in the form of crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07897603B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-ff3233e750fb431f84f96d39c4cb6b6d |
| Source note | uspto-grants-2011_03 |