HCID 86589699, compound → Octadecanoic acid, hydrazide

HRID 600177Notes

Reaction equation

HRID 600177 reaction equation
C(O[C:6](=[O:9])[NH:7][NH2:8])(C)(C)C.[C:10](O)(=O)[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]C>FC(F)(F)C(O)=O>[C:6]([NH:7][NH2:8])(=[O:9])[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH3:10]

Participants

3

Reactant 1

HCID 86589699HCID 86589699, compound

Product 1

HCID 20088Octadecanoic acid, hydrazideYield 76.3%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

1.8 g (4.52 mmol) stearic acid tert-butylcarbazate is dissolved in 3 ml trifluoracetic acid, stirred for 15 min and the solvent is removed under vacuum. The mixture is treated with 30 ml dry ether and the precipitate formed is filtered out and washed twice with 50 ml dry diethyl ether. After drying under high vacuum, 1.03 g stearic acid hydrazide is obtained; Rf=0.66 (ethyl acetate/methanol 1/1)

Workup

  1. customthe solvent is removed under vacuum
  2. additionThe mixture is treated with 30 ml dry ether
  3. customthe precipitate formed
  4. filtrationis filtered out
  5. washwashed twice with 50 ml dry diethyl ether
  6. customAfter drying under high vacuum

Sources & evidence

ORD record
ord-6caa6623a9984648b0bb8e2d2786c550
Source dataset
uspto-grants-2011_03
Patent number
US07902144B2

Reaction notes

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