2-Chloro-4-aminopyrimidine → HCID 42631890, compound

HRID 600216Notes

Reaction equation

HRID 600216 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH2:8])[CH:5]=[CH:4][N:3]=1.[CH:9]1([N:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)[CH2:13][CH2:12][CH2:11][CH2:10]1>CN(C=O)C>[CH:9]1([N:14]2[CH2:15][CH2:16][N:17]([C:2]3[N:7]=[C:6]([NH2:8])[CH:5]=[CH:4][N:3]=3)[CH2:18][CH2:19]2)[CH2:10][CH2:11][CH2:12][CH2:13]1

Participants

4

Reactant 2

HCID 3457522-Chloro-4-aminopyrimidineHCID 8064211-Cyclopentylpiperazine

Product 1

HCID 42631890HCID 42631890, compoundYield 51%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
70 °C

Procedure

A mixture of 0.5 g (3.86 mmol) 2-chloro-4-pyrimidinylamine (commercially available) and 1-cyclopentyl-piperazine (commercially available) in 1 mL DMF was heated to 70° C. for 16 h. The residue after filtration washed with diethyl ether and dried to yield 0.49 g (51%) of the title compound (intermediate 1) as white solid. MS (m/e): 284.3 (MH+).

Workup

  1. filtrationThe residue after filtration
  2. washwashed with diethyl ether
  3. customdried

Sources & evidence

ORD record
ord-3704bcd159ab4e5f942350a90ea90c77
Source dataset
uspto-grants-2011_03
Patent number
US07902184B2

Reaction notes

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