1-Ethylpiperazine → HCID 57502124, compound

HRID 600218Notes

Reaction equation

HRID 600218 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6](Cl)[N:5]=[CH:4][N:3]=1.[CH2:9]([N:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1)[CH3:10]>C1(C)C=CC=CC=1>[CH2:9]([N:11]1[CH2:16][CH2:15][N:14]([C:6]2[N:5]=[CH:4][N:3]=[C:2]([NH2:1])[CH:7]=2)[CH2:13][CH2:12]1)[CH3:10]

Participants

4

Reactant 2

HCID 791961-EthylpiperazineHCID 2380124-Amino-6-chloropyrimidine

Product 1

HCID 57502124HCID 57502124, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
110 °C

Procedure

A mixture of 1 g (7.7 mmol) 4-amino-6-chloropyrimidine (commercially available) and 1.75 g (15.4 mmol) 1-ethyl piperazine (commercially available) in 10 mL toluene was heated to 110° C. for 16 h. After evaporation of all volatiles the residue was purified by flash column chromatography on silica eluting with a gradient formed from DCM (0.5% NEt3) and methanol. The combined product fractions were evaporated to dryness to yield the title compound. MS (m/e): 208.3 (MH+).

Workup

  1. customAfter evaporation of all volatiles the residue
  2. customwas purified by flash column chromatography on silica eluting with a gradient
  3. customformed from DCM (0.5% NEt3) and methanol
  4. customThe combined product fractions were evaporated to dryness

Sources & evidence

ORD record
ord-73e123f4a49e4844a05a292278ef019a
Source dataset
uspto-grants-2011_03
Patent number
US07902184B2

Reaction notes

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