HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzylamine → (6-Benzylamino-5,6,7,8-tetrahydro-naphthalen-2-yl)-(2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | (S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidine | HCID 853152 | — |
| Reactant | 6-Bromo-2-tetralone | HCID 2733553 | — |
| Reactant | Benzyl-(6-bromo-1,2,3,4-tetrahydro-naphthalen-2-yl)-amine | HCID 59486428 | — |
| Product | (6-Benzylamino-5,6,7,8-tetrahydro-naphthalen-2-yl)-(2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone | HCID 67273291 | — |
Reaction Steps
(6-Benzylamino-5,6,7,8-tetrahydro-naphthalen-2-yl)-(2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone is prepared from benzyl-(6-bromo-1,2,3,4-tetrahydro-naphthalen-2-yl)-amine and (S)-(+)-1-(2-pyrrolidinylmethyl)-pyrrolidine in a manner substantially analogous to Procedure A. (See herein Example 1). Starting material, benzyl-(6-bromo-1,2,3,4-tetrahydro-naphthalen-2-yl)-amine, can be prepared from 6-bromo-2-tetralone and benzylamine in a manner substantially analogous to Preparation 1. Mass spectrum (APCI) 418 (M++1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07902191B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-6b4fc8a167024292aaef190d64e53131 |
| Source note | uspto-grants-2011_03 |