Butylamine → HCID 67273095, compound

HRID 600246Notes

Reaction equation

HRID 600246 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][CH:7]([NH:12][CH2:13][CH2:14][CH2:15][CH3:16])[CH2:6][CH2:5]2.[NH:17]1[CH2:21][CH2:20][CH2:19][C@H:18]1[CH2:22][N:23]1[CH2:27][CH2:26][CH2:25][CH2:24]1.BrC1C=C2C(=CC=1)C[C:34](=[O:39])CC2.C(N)CCC>>[CH2:13]([NH:12][CH:7]1[CH2:6][CH2:5][C:4]2[CH:3]=[C:2]([C:34]([N:17]3[CH2:21][CH2:20][CH2:19][CH:18]3[CH2:22][N:23]3[CH2:27][CH2:26][CH2:25][CH2:24]3)=[O:39])[CH:11]=[CH:10][C:9]=2[CH2:8]1)[CH2:14][CH2:15][CH3:16]

Participants

5

Reactant 4

HCID 8007ButylamineHCID 853152(S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidineHCID 27335536-Bromo-2-tetraloneHCID 63625845HCID 63625845, compound2×

Product 1

HCID 67273095HCID 67273095, compound

Procedure

(6-Butylamino-5,6,7,8-tetrahydro-naphthalen-2-yl)-(2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone is prepared from (6-bromo-1,2,3,4-tetrahydro-naphthalen-2-yl)-butyl-amine and (S)-(+)-1-(2-pyrrolidinylmethyl)-pyrrolidine in a manner substantially analogous to Procedure A. (See herein Example 1). Starting material, (6-bromo-1,2,3,4-tetrahydro-naphthalen-2-yl)-butyl-amine, was prepared from 6-bromo-2-tetralone and n-butylamine in a manner substantially analogous to Preparation 1. Mass spectrum (APCI) 384 (M++1).

Sources & evidence

ORD record
ord-e920fe347c4f450892e43e6bb2fced5e
Source dataset
uspto-grants-2011_03
Patent number
US07902191B2

Reaction notes

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