反应详情

To a solution of {3-[2-fluoro-5-(4-oxo-3,4-dihydro-phthalazin-1-ylmethyl)-phenyl]-5-methyl-2,4-dioxo-imidazolidin-1-yl}-acetic acid tert-butyl ester (35A)(1.3 g, 2.7 mmol) in dry DCM (20 ml) was added trifluoroacetic acid (2 mL, ca 27 mmol) dropwise over 2 minutes. After overnight stirring the reaction mixture was concentrated to dryness and subjected to flash chromatography. Eluent 1% acetic acid in ethyl acetate. The title compound was isolated as a white solid. Single peak in LC-MS analysis, (0.680 mg, 100% purity) and required no further purification; m/z (LC-MS, ESN), RT=2.95 mins (M−H) 423

1. concentrationwas concentrated to dryness