反应详情

温度

50 °C

(S)-tert-Butyl 1-cyano-2-(4-iodophenyl)ethylcarbamate (1.4 g) and formic acid (3 mL) were combined and heated at 50° C. for 10 min. Solvent was removed in vacuo and crude material was loaded onto an SCX cartridge. Non-basic impurities were washed off with methanol, then product was eluted with 10% ammonia in methanol. Solvent was removed in vacuo to give (S)-2-amino-3-(4-iodophenyl)propanenitrile (0.900 g).

1. customSolvent was removed in vacuo and crude material
2. washNon-basic impurities were washed off with methanol
3. washproduct was eluted with 10% ammonia in methanol
4. customSolvent was removed in vacuo