(S)-Tert-butyl (1-cyano-2-(4-iodophenyl)ethyl)carbamate → (S)-2-amino-3-(4-iodophenyl)propanenitrile

Participants

Reaction Conditions

Reaction Steps

(S)-tert-Butyl 1-cyano-2-(4-iodophenyl)ethylcarbamate (1.4 g) and formic acid (3 mL) were combined and heated at 50° C. for 10 min. Solvent was removed in vacuo and crude material was loaded onto an SCX cartridge. Non-basic impurities were washed off with methanol, then product was eluted with 10% ammonia in methanol. Solvent was removed in vacuo to give (S)-2-amino-3-(4-iodophenyl)propanenitrile (0.900 g).

Provenance & Evidence