反应详情

温度

50 °C

(S)-tert-Butyl 1-cyano-2-(4′-cyano-3′-fluorobiphenyl-4-yl)ethylcarbamate (0.580 g) was stirred in formic acid (8 mL) and heated at 50° C. for 10 min. The cooled mixture was evaporated, dissolved in methanol and applied to a 10 g SCX column. The column was washed with methanol then eluted with 10% ammonia in methanol. The eluate was evaporated to give a solid (0.335 g).

1. customThe cooled mixture was evaporated
2. dissolutiondissolved in methanol
3. washThe column was washed with methanol
4. washthen eluted with 10% ammonia in methanol
5. customThe eluate was evaporated