(S)-tert-Butyl 1-cyano-2-(4'-cyano-3'-fluorobiphenyl-4-yl)ethylcarbamate → (S)-4'-(2-Amino-2-cyanoethyl)-3-fluorobiphenyl-4-carbonitrile

Participants

Reaction Conditions

Reaction Steps

(S)-tert-Butyl 1-cyano-2-(4′-cyano-3′-fluorobiphenyl-4-yl)ethylcarbamate (0.580 g) was stirred in formic acid (8 mL) and heated at 50° C. for 10 min. The cooled mixture was evaporated, dissolved in methanol and applied to a 10 g SCX column. The column was washed with methanol then eluted with 10% ammonia in methanol. The eluate was evaporated to give a solid (0.335 g).

Provenance & Evidence