反应详情

(S)-tert-Butyl 1-amino-3-(6-bromopyridin-3-yl)-1-oxopropan-2-ylcarbamate (1.5 g) was dissolved in DCM (20 mL) and to the solution was added TFA (10 mL). The reaction mixture was stirred for 0.5 h then concentrated in vacuo. Crude material was dissolved in methanol and loaded onto an SCX cartridge. Non-basic impurities were washed off with methanol, then product was eluted with 10% ammonia in methanol to give the sub-title compound (1.0 g).

1. concentrationthen concentrated in vacuo
2. dissolutionCrude material was dissolved in methanol
3. washNon-basic impurities were washed off with methanol
4. washproduct was eluted with 10% ammonia in methanol