反应详情

Triethylamine (3.46 mL) in DCM (5 mL) was stirred under nitrogen and to the solution was added a solution of methyl chlorosulfonylcarbamate (1.658 g) in DCM (5 mL). The mixture was stirred at room temperature for 15 min then a solution of (S)-tert-butyl 2-((S)-1-amino-3-(6-bromopyridin-3-yl)-1-oxopropan-2-ylcarbamoyl)piperidine-1-carboxylate (1.74 g) in DCM (5 mL) was added. Stirring was continued overnight. The reaction mixture was washed with water then brine, dried over magnesium sulfate, filtered and concentrated in vacuo. Crude product was purified by flash silica chromatography eluting with 40% ethyl acetate in isohexane to give the title compound (1.2 g) as a white solid.

1. stirringStirring
2. waitwas continued overnight
3. washThe reaction mixture was washed with water
4. dry with materialbrine, dried over magnesium sulfate
5. filtrationfiltered
6. concentrationconcentrated in vacuo
7. customCrude product was purified by flash silica chromatography
8. washeluting with 40% ethyl acetate in isohexane