Ethanol → Ethyl 2-[3-[6-(azetidine-1-carbonyl)pyridin-3-yl]oxy-5-[(5-methylpyrazin-2-yl)carbamoyl]phenoxy]-4-hydroxy-butanoate

Participants

Reaction Steps

Potassium carbonate (113 mg, 0.82 mmol) was added to a solution of 3-[6-(azetidine-1-carbonyl)pyridin-3-yl]oxy-N-(5-methylpyrazin-2-yl)-5-(2-oxooxolan-3-yl)oxy-benzamide (Intermediate 29) (800 mg, 1.6 mmol) in ethanol (80 mL) at 0° C. under nitrogen. The reaction was allowed to warm to RT and stirred for 4 hours. The reaction mixture was filtered through silica, washing well with ethyl acetate, and concentrated to afford crude product which was used directly in the next stage without further purification.

Provenance & Evidence