反应详情

Potassium carbonate (113 mg, 0.82 mmol) was added to a solution of 3-[6-(azetidine-1-carbonyl)pyridin-3-yl]oxy-N-(5-methylpyrazin-2-yl)-5-(2-oxooxolan-3-yl)oxy-benzamide (Intermediate 29) (800 mg, 1.6 mmol) in ethanol (80 mL) at 0° C. under nitrogen. The reaction was allowed to warm to RT and stirred for 4 hours. The reaction mixture was filtered through silica, washing well with ethyl acetate, and concentrated to afford crude product which was used directly in the next stage without further purification.

1. filtrationThe reaction mixture was filtered through silica
2. washwashing well with ethyl acetate
3. concentrationconcentrated
4. customto afford crude product which
5. customwas used directly in the next stage without further purification