N-bromobutanimide → HCID 178448705, compound

HRID 600611Notes

Reaction equation

HRID 600611 reaction equation
[CH2:1]([N:5]1[C:13]2[NH:12][CH:11]=[N:10][C:9]=2[C:8]2=[N:14][N:15]=[CH:16][N:7]2[C:6]1=[O:17])[CH:2]([CH3:4])[CH3:3].[Br:18]N1C(=O)CCC1=O>C1COCC1>[Br:18][C:11]1[NH:12][C:13]2[N:5]([CH2:1][CH:2]([CH3:4])[CH3:3])[C:6](=[O:17])[N:7]3[CH:16]=[N:15][N:14]=[C:8]3[C:9]=2[N:10]=1

Participants

4

Reactant 2

HCID 67184N-bromobutanimideHCID 178448706HCID 178448706, compound

Product 1

HCID 178448705HCID 178448705, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 6-isobutyl-6,7-dihydro-5h-[1,2,4]triazolo[3,4-i]purin-5-one (9.4 mg, 40 mmol) in THF (5 ml) was added N-bromosuccinimide (8 mg, 44.7 mmol). The mixture was stirred at room temperature for 30 minutes. The reaction mixture was concentrated, and the residue was purified by preparative LCMS (method A) to provide the desired product. LCMS calculated for C10H12BrN6O (M+H): 311.0. found 310.9, 313.0.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was purified by preparative LCMS (method A)

Sources & evidence

ORD record
ord-0d964d1ec7024c1c848402d473d61ef3
Source dataset
uspto-grants-2011_03
Patent number
US07902205B2

Reaction notes

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