Sodium Hydroxide → HCID 67273847, compound

HRID 600623Notes

Reaction equation

HRID 600623 reaction equation
[C:1]([C:9]1[N:10]=[C:11]2[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][N:12]2[CH:20]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+].S(S([O-])=O)([O-])=O.[Na+].[Na+]>C(O)C>[NH2:17][C:14]1[CH:15]=[CH:16][C:11]2[N:12]([CH:20]=[C:9]([C:1]([C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)=[O:8])[N:10]=2)[CH:13]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 24489Sodium DithioniteHCID 67273481HCID 67273481, compound

Product 1

HCID 67273847HCID 67273847, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.42 g of 2-benzoyl-6-nitroimidazo[1,2-a]pyridine in 20 mL of boiling ethanol is treated with 10 mL of 0.5 N sodium hydroxide solution and 2.77 g of sodium dithionite. After 10 minutes at 80° C., the reaction medium is cooled, filtered and concentrated to dryness to give the crude (6-aminoimidazo[1,2-a]pyridin-2-yl)(phenyl)methanone, which is used without further purification.

Workup

  1. temperaturethe reaction medium is cooled
  2. filtrationfiltered
  3. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-598a927f9d684d0b937799d8892e411e
Source dataset
uspto-grants-2011_03
Patent number
US07902219B2

Reaction notes

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