反应详情

温度

35 °C

Vemurafenib (Form 2, 0.5 g, 1.02 mmol) was suspended in 5 mL acetone and the mixture was warmed to 35° C. While maintaining this temperature, 0.8 ml of 1.25 M HCl in ethanol (approximately 1 equivalent) were added dropwise. A clear solution was obtained. Thereafter, the solution was allowed to cool to RT and stirred overnight. The obtained precipitate was filtered, washed with acetone and dried under ambient conditions (RT, atmospheric pressure) for approximately 20 h. Yield: 0.49 g (91%).

1. additionwere added dropwise
2. customA clear solution was obtained
3. temperatureto cool to RT
4. filtrationThe obtained precipitate was filtered
5. washwashed with acetone
6. customdried under ambient conditions (RT, atmospheric pressure) for approximately 20 h