HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 71617851, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Vemurafenib | HCID 42611257 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 71617851 | HCID 71617851 | — |
Reaction Steps
The procedure was identical to that described in Example 2 with the following modification: 1.0 ml of 1M HCl in diethylether instead of 0.8 ml of 1.25 M HCl in ethanol, corresponding to 1 equivalent of HCl, was added to the suspension of 0.5 g Vemurafenib in 5 ml acetone. Yield: 0.50 g (93%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09440971B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-f3cad72438cc456184deea419fa201f2 |
| Source note | uspto-grants-2016_09 |