反应详情

The procedure was identical to that described in Example 2 with the following modification: 1.0 ml of 1M HCl in diethylether instead of 0.8 ml of 1.25 M HCl in ethanol, corresponding to 1 equivalent of HCl, was added to the suspension of 0.5 g Vemurafenib in 5 ml acetone. Yield: 0.50 g (93%)