Hydrochloric Acid → HCID 71617851, compound

Participants

Reaction Conditions

Reaction Steps

Vemurafenib (97.8 g, 199.6 mmol) was suspended in 900 mL acetone and the mixture was warmed to 35° C. While maintaining this temperature, 200 ml of 1.25 M HCl in ethanol (250 mmol HCl, 1.25 equivalents) were added dropwise. A clear solution was obtained. Thereafter, the solution was stirred for another 5 min at 35° C. and then allowed to cool to RT and stirred overnight. The obtained precipitate was filtered, washed with acetone and dried at 40° C. under reduced pressure (30 mbar) for approximately 16 h. Yield: 95.8 g (91%)

Provenance & Evidence