反应详情

温度

35 °C

Vemurafenib (97.8 g, 199.6 mmol) was suspended in 900 mL acetone and the mixture was warmed to 35° C. While maintaining this temperature, 200 ml of 1.25 M HCl in ethanol (250 mmol HCl, 1.25 equivalents) were added dropwise. A clear solution was obtained. Thereafter, the solution was stirred for another 5 min at 35° C. and then allowed to cool to RT and stirred overnight. The obtained precipitate was filtered, washed with acetone and dried at 40° C. under reduced pressure (30 mbar) for approximately 16 h. Yield: 95.8 g (91%)

1. additionwere added dropwise
2. customA clear solution was obtained
3. temperatureto cool to RT
4. stirringstirred overnight
5. filtrationThe obtained precipitate was filtered
6. washwashed with acetone
7. customdried at 40° C. under reduced pressure (30 mbar) for approximately 16 h