Trifluoroacetic acid → HCID 46853727, compound

HRID 600731Notes

Reaction equation

HRID 600731 reaction equation
Cl[C:2]1C=[CH:6][C:5]([C:8]2[CH:12]3[CH2:13][N:14]([C:16]4[N:25]=[C:24]5[C:19]([C:20](=[O:37])[C:21]([C:34]([OH:36])=[O:35])=[CH:22][N:23]5[C:26]5[CH:31]=[CH:30][C:29]([F:32])=[CH:28][C:27]=5[F:33])=[CH:18][C:17]=4[F:38])[CH2:15][CH:11]3[O:10][N:9]=2)=[CH:4][CH:3]=1.C(O)(C(F)(F)F)=O.FC(F)(F)C(O)=O.[N:53]1C=CC=C(C2[C@@H]3CNC[C@@H]3ON=2)C=1>>[F:33][C:27]1[CH:28]=[C:29]([F:32])[CH:30]=[CH:31][C:26]=1[N:23]1[C:24]2[C:19](=[CH:18][C:17]([F:38])=[C:16]([N:14]3[CH2:15][CH:11]4[CH:12]([C:8]([C:5]5[CH:6]=[N:53][CH:2]=[CH:3][CH:4]=5)=[N:9][O:10]4)[CH2:13]3)[N:25]=2)[C:20](=[O:37])[C:21]([C:34]([OH:36])=[O:35])=[CH:22]1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 25206945HCID 25206945, compoundHCID 68973190HCID 68973190, compound

Product 1

HCID 46853727HCID 46853727, compound

Procedure

The title compound was prepared in an analogous manner to acid 101, but using a suitably substituted TFA salt 4f. Acid 105 was isolated as a beige solid.

Sources & evidence

ORD record
ord-c4ee9385faea497699bd005428a2bfb9
Source dataset
uspto-grants-2011_03
Patent number
US07902227B2

Reaction notes

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