Trifluoroacetic acid → HCID 57555547, compound

HRID 600732Notes

Reaction equation

HRID 600732 reaction equation
ClC1C=C[C:5]([C:8]2[CH:12]3[CH2:13][N:14]([C:16]4[N:25]=[C:24]5[C:19]([C:20](=[O:37])[C:21]([C:34]([OH:36])=[O:35])=[CH:22][N:23]5[C:26]5[CH:31]=[CH:30][C:29]([F:32])=[CH:28][C:27]=5[F:33])=[CH:18][C:17]=4[F:38])[CH2:15][CH:11]3[O:10][N:9]=2)=CC=1.C(O)(C(F)(F)F)=[O:40]>>[F:33][C:27]1[CH:28]=[C:29]([F:32])[CH:30]=[CH:31][C:26]=1[N:23]1[C:24]2[C:19](=[CH:18][C:17]([F:38])=[C:16]([N:14]3[CH2:15][CH:11]4[CH:12]([C:8]([CH2:5][OH:40])=[N:9][O:10]4)[CH2:13]3)[N:25]=2)[C:20](=[O:37])[C:21]([C:34]([OH:36])=[O:35])=[CH:22]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 25206945HCID 25206945, compound

Product 1

HCID 57555547HCID 57555547, compound

Procedure

The title compound was prepared in an analogous manner to acid 101, but using a suitably substituted TFA salt 11. Acid 107 was isolated as a beige solid.

Sources & evidence

ORD record
ord-423853ebf4ad4121a3ebb86e02b8bfbe
Source dataset
uspto-grants-2011_03
Patent number
US07902227B2

Reaction notes

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