3-Pyrroline → HCID 57555576, compound

HRID 600733Notes

Reaction equation

HRID 600733 reaction equation
[NH:1]1[CH2:5][CH:4]=[CH:3][CH2:2]1.Cl[C:7]1[N:16]=[C:15]2[C:10]([C:11](=[O:23])[C:12]([C:20]([OH:22])=[O:21])=[CH:13][N:14]2[CH:17]2[CH2:19][CH2:18]2)=[CH:9][C:8]=1[F:24]>C(#N)C>[CH:17]1([N:14]2[C:15]3[C:10](=[CH:9][C:8]([F:24])=[C:7]([N:1]4[CH2:5][CH:4]=[CH:3][CH2:2]4)[N:16]=3)[C:11](=[O:23])[C:12]([C:20]([OH:22])=[O:21])=[CH:13]2)[CH2:18][CH2:19]1

Participants

4

Reactant 2

HCID 660593-PyrrolineHCID 110551427-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Product 1

HCID 57555576HCID 57555576, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

3-Pyrroline (1.0 g; 14.5 mmol) and acid 51 (2.0 g; 7.1 mmol) in acetonitrile (50 mL) were heated at reflux temperature overnight. The volatiles were evaporated and water added to the residue. The resulting solid was filtered, washed with water and ether to yield 109 as a beige solid.

Workup

  1. temperatureat reflux temperature overnight
  2. customThe volatiles were evaporated
  3. additionwater added to the residue
  4. filtrationThe resulting solid was filtered
  5. washwashed with water and ether

Sources & evidence

ORD record
ord-bb6d1ab20d784b1aa8742cb6f3415d0f
Source dataset
uspto-grants-2011_03
Patent number
US07902227B2

Reaction notes

Loading…