HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Pyrroline → HCID 57555576, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Pyrroline | HCID 66059 | — |
| Reactant | 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid | HCID 11055142 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 57555576 | HCID 57555576 | — |
Reaction Steps
3-Pyrroline (1.0 g; 14.5 mmol) and acid 51 (2.0 g; 7.1 mmol) in acetonitrile (50 mL) were heated at reflux temperature overnight. The volatiles were evaporated and water added to the residue. The resulting solid was filtered, washed with water and ether to yield 109 as a beige solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07902227B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-bb6d1ab20d784b1aa8742cb6f3415d0f |
| Source note | uspto-grants-2011_03 |