Trifluoroacetic acid → HCID 68973293, compound

HRID 600737Notes

Reaction equation

HRID 600737 reaction equation
CO[C:3]1[CH:8]=C[C:6]([C:9]2[C@@H:13]3[CH2:14][N:15]([C:17]4[C:26]([O:27][CH3:28])=[C:25]5[C:20]([C:21](=[O:35])[C:22]([C:32]([OH:34])=[O:33])=[CH:23][N:24]5[CH:29]5[CH2:31][CH2:30]5)=[CH:19][C:18]=4F)[CH2:16][C@@H:12]3[O:11][N:10]=2)=[CH:5][CH:4]=1.C(O)(C(F)(F)F)=O.FC(F)(F)C(O)=O.[N:51]1C=CC=CC=1C1[C@@H]2CNC[C@@H]2ON=1>>[N:51]1[CH:8]=[CH:3][CH:4]=[CH:5][C:6]=1[C:9]1[C@@H:13]2[CH2:14][N:15]([C:17]3[C:26]([O:27][CH3:28])=[C:25]4[C:20]([C:21](=[O:35])[C:22]([C:32]([OH:34])=[O:33])=[CH:23][N:24]4[CH:29]4[CH2:31][CH2:30]4)=[CH:19][CH:18]=3)[CH2:16][C@@H:12]2[O:11][N:10]=1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 68970806HCID 68970806, compoundHCID 68974986HCID 68974986, compound

Product 1

HCID 68973293HCID 68973293, compound

Procedure

The title compound was prepared according to the procedure for the synthesis of 120, but using activated core 71 and TFA salt 4e. Acid 150 was isolated in 23% yield.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-759240235c1e4403a07e0fc80dc5a6a8
Source dataset
uspto-grants-2011_03
Patent number
US07902227B2

Reaction notes

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