反应详情

To a solution of the product of Example 1C (14.47 g, 50.4 mmol) in dioxane (30 mL) at 0° C. was added 4N HCl in dioxane (60 mL, 240 mmol). The reaction mixture was stirred at room temperature for 3.5 hours, diluted with 3 volumes of diethyl ether. The resulting dark brown precipitate was collected by filtration. It was then treated with saturated NaHCO3 solution and was extracted with ethyl acetate. The solution was dried over MgSO4, filtered and evaporated in vacuo to yield the title compound (4.88 g, 52%).

1. filtrationThe resulting dark brown precipitate was collected by filtration
2. additionIt was then treated with saturated NaHCO3 solution
3. extractionwas extracted with ethyl acetate
4. dry with materialThe solution was dried over MgSO4
5. filtrationfiltered
6. customevaporated in vacuo