8-{5-[4-(Trifluoromethyl)phenyl]oxazol-2-ylamino}-3,4-dihydronaphthalen-2(1H)-one → HCID 11964288, compound

HRID 600790Notes

Reaction equation

HRID 600790 reaction equation
[C:1]12([C:11]3[O:15][C:14]([NH:16][C:17]4[CH:18]=[CH:19][CH:20]=[C:21]5[C:26]=4[CH2:25][C:24](=[O:27])[CH2:23][CH2:22]5)=[N:13][CH:12]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.FC(F)(F)C1C=CC(C2OC(NC3C=CC=C4C=3CC(=O)CC4)=NC=2)=CC=1>>[C:1]12([C:11]3[O:15][C:14]([NH:16][C:17]4[CH:18]=[CH:19][CH:20]=[C:21]5[C:26]=4[CH2:25][CH:24]([OH:27])[CH2:23][CH2:22]5)=[N:13][CH:12]=3)[CH2:10][CH:5]3[CH2:4][CH:3]([CH2:9][CH:7]([CH2:6]3)[CH2:8]1)[CH2:2]2

Participants

3

Reactant 2

HCID 119558408-{5-[4-(Trifluoromethyl)phenyl]oxazol-2-ylamino}-3,4-dihydronaphthalen-2(1H)-oneHCID 11964287HCID 11964287, compound

Product 1

HCID 11964288HCID 11964288, compound

Procedure

The title compound was prepared using the procedure as described in Example 2, substituting the product of Example 12C for the product of Example 1I. 1H NMR (DMSO-d6) δ 8.64 (s, 1H), 7.55 (d, 1H, J=7.7 Hz), 7.05 (t, 1H, J=7.6 Hz), 6.77 (d, 1H, J=7.1 Hz), 6.41 (s, 1H), 4.76 (d, 1H, J=4.1 Hz), 3.90 (m, 1H), 2.72-2.94 (m, 3H), 1.63-2.05 (m, 18H); MS (ESI+) m/z 365 (M+H)+.

Sources & evidence

ORD record
ord-0ee6a6a36fbc4e04ade63a853329fbbd
Source dataset
uspto-grants-2011_03
Patent number
US07902236B2

Reaction notes

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