反应详情

A mixture of 3-benzylrhodanine (0.50 g, 2.2 mmol), benzaldehyde (0.23 mL, 2.3 mmol) and TEA (0.68 mL, 4.9 mmol) in MeCN (5 mL, anhyd) was heated at reflux. After 2 h the reaction mixture was cooled. Precipitated solids were collected by filtration, triturated with MeCN-Hex and dried under vacuum to yield 3-benzyl-5-benzylidene-2-thioxothiazolidin-4-one, which was used without further purification.

1. temperatureanhyd) was heated
2. temperatureat reflux
3. temperatureAfter 2 h the reaction mixture was cooled
4. customPrecipitated solids
5. filtrationwere collected by filtration
6. customtriturated with MeCN-Hex
7. customdried under vacuum