Hydrochloric Acid → HCID 67271343, compound

HRID 600836Notes

Reaction equation

HRID 600836 reaction equation
C(OC([N:8]1[C@@H:12]([CH2:13][N:14]([CH:21]([CH3:23])[CH3:22])[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:11][O:10]C1(C)C)=O)(C)(C)C.[ClH:26]>O1CCOCC1>[ClH:26].[ClH:26].[NH2:8][C@@H:12]([CH2:13][N:14]([CH:21]([CH3:23])[CH3:22])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[CH2:11][OH:10]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57667096HCID 57667096, compound

Product 1

HCID 67271343HCID 67271343, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a stirred solution of (S)-4-[(isopropyl-phenyl-amino)-methyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (650 mg) in dioxane (5 ml) under an argon atmosphere was added HCl solution (4M in dioxane; 9.33 ml). The mixture was stirred overnight. The mixture was concentrated and the residue was dried to give (S)-2-amino-3-(isopropyl-phenyl-amino)-propan-1-ol dihydrochloride (616 mg, quant.) as off-white amorphous solid. MS (ISP): 209.3 ([M+H]+)

Workup

  1. concentrationThe mixture was concentrated
  2. customthe residue was dried

Sources & evidence

ORD record
ord-a252d9cb9e9048b787920082b8886e3a
Source dataset
uspto-grants-2011_03
Patent number
US07902238B2

Reaction notes

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