反应详情

Ethyl 7-fluoro-1-[2-(S)-fluoro-1-(R)-cyclopropyl]-1,4-dihydro-8-methyl-4-oxoquinoline-3-carboxylate (1.40 g, 4.56 mmol) was dissolved in acetic acid (4 ml), and after adding concentrated hydrochloric acid (4 ml) thereto, it was heated under reflux for 3 hours. After cooling, the reaction solution was poured into ice water (50 ml) and the precipitated crystals were filtered out. After washing the filtered-out crystals with an excess amount of water, washing in cold ethanol and washing in diethyl ether were performed in that order, and after drying under a reduced pressure, 1.18 g (93%) of the title compound was obtained in the form of a white powder.

1. temperatureit was heated
2. temperatureunder reflux for 3 hours
3. temperatureAfter cooling
4. filtrationthe precipitated crystals were filtered out
5. washAfter washing the filtered-out crystals with an excess amount of water
6. washwashing in cold ethanol
7. washwashing in diethyl ether
8. customafter drying under a reduced pressure