反应详情

4-(1-ethoxycarbonylcyclopropyl)-1-[1-(S)-phenylethyl]-3-pyrrolin-2-one (12.1 g, 40.5 mmol) was dissolved in ethyl acetate (120 ml), a 5% platinum carbon catalyst (water content: 50%, 2.4 g) was added thereto, and it was stirred at room temperature for 17 hours under a hydrogen atmosphere at atmospheric pressure. The reaction solution was then filtered through cellite (washed with ethyl acetate) and the filtrate was then concentrated under a reduced pressure. The concentrate was applied to a silica gel chromatography, and 9.00 g (74%) of the compound of the title were obtained as a pale-yellow syrup from an n-hexane:ethyl acetate=3:2 eluate. Further, 2.60 g (21%) of the diastereomer (4-(R)-isomer) of the title compound was obtained as a pale-yellow syrup. The instrumental analysis data for this resulting compound agreed with the data indicated in PCT/JP96/00208.

1. filtrationThe reaction solution was then filtered through cellite (washed with ethyl acetate)
2. concentrationthe filtrate was then concentrated under a reduced pressure
3. customwere obtained as a pale-yellow syrup from an n-hexane