反应详情

温度

140 °C

Into a microwave vial, 5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-indazole (12, 28 mg, 0.11 mmol) is combined with N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-2,5-difluoro-benzenesulfonamide (26, 50 mg, 0.09 mmol), tetrakis(triphenylphosphine)palladium(0) (2.2 mg, 0.0019 mmol), and potassium carbonate (1.0 mL, 1.0 M in water) in 3 mL of acetonitrile. The reaction is heated at 140° C. for 50 minutes in a microwave, the solvents removed under vacuum, and the residue purified by silica gel column chromatography, eluting with dichloromethane and methanol. Appropriate fractions are combined and concentrated under vacuum to provide the desired compound as a white solid (P-0002, 28 mg, 50%). MS (ESI) [M+H+]+=565.85.

1. customthe solvents removed under vacuum
2. customthe residue purified by silica gel column chromatography
3. washeluting with dichloromethane and methanol
4. concentrationconcentrated under vacuum