Hydrazine hydrate (1:1) → 4-Hydrazino-6-(4-methylpiperazin-1-yl)pyrimidine

HRID 601008Notes

Reaction equation

HRID 601008 reaction equation
Cl[C:2]1[CH:7]=[C:6]([N:8]2[CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][CH2:9]2)[N:5]=[CH:4][N:3]=1.O.[NH2:16][NH2:17]>>[CH3:14][N:11]1[CH2:12][CH2:13][N:8]([C:6]2[N:5]=[CH:4][N:3]=[C:2]([NH:16][NH2:17])[CH:7]=2)[CH2:9][CH2:10]1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 81780744-Chloro-6-(4-methylpiperazin-1-yl)pyrimidine

Product 1

HCID 133936264-Hydrazino-6-(4-methylpiperazin-1-yl)pyrimidine

Procedure

4-Chloro-6-(4-methyl-piperazin-1-yl)-pyrimidine, (200 mg, 0.94 mmol), and hydrazine hydrate, (200 μl, 4 mmol), were heated to 180° for 6 min in a Personal Chemistry Microwave. The solvent was evaporated affording [6-(4-Methyl-piperazin-1-yl)-pyrimidin-4-yl]-hydrazine as yellow brown crystals which were used without further purification.

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-2678d7ba3fc8416dbb45e6ba5fd25ece
Source dataset
uspto-grants-2011_03
Patent number
US07902239B2

Reaction notes

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