Sodium Hydroxide → HCID 58976373, compound

Participants

Reaction Steps

1-(2-Methanesulfonyl-6-phenylamino-pyrimidin-4-yl)-N3-phenyl-1H-[1,2,4]triazole-3,5-diamine (12 mg, 0.028 mMol) was stirred at ambient temperature in 500 uL of DMF with 200 uL of 1N NaOH for 2 hrs. The reaction was quenched with water and a precipitate allowed come out of solution. The filtrate was decanted off and the solid was resuspended with water, allowed to settle, and again decanted. The solid was transferred to a round bottom flask with acetonitrile and the solvents removed under reduced pressure. The resultant material, a beige yellow solid, resulted in 90% yield.

Provenance & Evidence