Sodium Hydroxide → HCID 58976373, compound

HRID 601059Notes

Reaction equation

HRID 601059 reaction equation
CS([C:5]1[N:10]=[C:9]([N:11]2[C:15]([NH2:16])=[N:14][C:13]([NH:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[N:12]2)[CH:8]=[C:7]([NH:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[N:6]=1)(=O)=O.[OH-:31].[Na+]>CN(C=O)C>[NH2:16][C:15]1[N:11]([C:9]2[CH:8]=[C:7]([NH:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[NH:6][C:5](=[O:31])[N:10]=2)[N:12]=[C:13]([NH:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[N:14]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 58976043HCID 58976043, compound

Product 1

HCID 58976373HCID 58976373, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1-(2-Methanesulfonyl-6-phenylamino-pyrimidin-4-yl)-N3-phenyl-1H-[1,2,4]triazole-3,5-diamine (12 mg, 0.028 mMol) was stirred at ambient temperature in 500 uL of DMF with 200 uL of 1N NaOH for 2 hrs. The reaction was quenched with water and a precipitate allowed come out of solution. The filtrate was decanted off and the solid was resuspended with water, allowed to settle, and again decanted. The solid was transferred to a round bottom flask with acetonitrile and the solvents removed under reduced pressure. The resultant material, a beige yellow solid, resulted in 90% yield.

Workup

  1. customThe reaction was quenched with water
  2. customThe filtrate was decanted off
  3. customagain decanted
  4. customThe solid was transferred to a round bottom flask with acetonitrile
  5. customthe solvents removed under reduced pressure

Sources & evidence

ORD record
ord-5b165c7067e54b1ab1f4b370d86b1231
Source dataset
uspto-grants-2011_03
Patent number
US07902239B2

Reaction notes

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