Ethyl 2-[(2-ethylbutyl)amino]nicotinate → 1-Benzyl-7-methyl-2H-pyrido[2,3-d][1,3]oxazine-2,4(1H)-dione

HRID 601116Notes

Reaction equation

HRID 601116 reaction equation
[CH2:1]([NH:8][C:9]1[N:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:10]=1[C:11]([O-:13])=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1(C[NH3+])C=CC=CC=1.C(C(CC)CNC1N=CC=CC=1[C:34](OCC)=[O:35])C>>[CH2:1]([N:8]1[C:9]2[N:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:10]=2[C:11](=[O:13])[O:12][C:34]1=[O:35])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 67064133Ethyl 2-[(2-ethylbutyl)amino]nicotinateHCID 86592109HCID 86592109, compound

Product 1

HCID 497580431-Benzyl-7-methyl-2H-pyrido[2,3-d][1,3]oxazine-2,4(1H)-dione

Procedure

The title compound was prepared according to the procedure of Example 3B substituting the product of Example 62A for the product of Example 3A (0.150 g, 50%). 1H NMR (300 MHz, CDCl3) δ 2.66 (s, 3H), 5.47 (s, 2H), 7.10 (d, J=8.09 Hz, 1H), 7.31 (m, 3H), 7.55 (dd, J=7.54, 1.65 Hz, 2H), 8.26 (d, J=8.09 Hz, 1H).

Sources & evidence

ORD record
ord-4b358f14345a4690a9f0ace4a1e2b720
Source dataset
uspto-grants-2011_03
Patent number
US07902203B2

Reaction notes

Loading…