3-Aminopyridine → HCID 53261779, compound

HRID 60112Notes

Reaction equation

[F:1][C:2]1[C:21]([NH:22][S:23]([CH2:26][CH2:27][CH3:28])(=[O:25])=[O:24])=[CH:20][CH:19]=[C:18]([F:29])[C:3]=1[C:4]([C:6]1[C:14]2[C:9](=[N:10][CH:11]=[C:12]([C:15](O)=[O:16])[CH:13]=2)[NH:8][CH:7]=1)=[O:5].[N:30]1[CH:35]=[CH:34][CH:33]=[C:32]([NH2:36])[CH:31]=1>>[N:30]1[CH:35]=[CH:34][CH:33]=[C:32]([NH:36][C:15]([C:12]2[CH:13]=[C:14]3[C:6]([C:4](=[O:5])[C:3]4[C:18]([F:29])=[CH:19][CH:20]=[C:21]([NH:22][S:23]([CH2:26][CH2:27][CH3:28])(=[O:25])=[O:24])[C:2]=4[F:1])=[CH:7][NH:8][C:9]3=[N:10][CH:11]=2)=[O:16])[CH:31]=1

Participants

Reactant 2

HCID 100093-Aminopyridine

HCID 58087848HCID 58087848, compound

Product 1

HCID 53261779HCID 53261779, compound

Procedure

3-[2,6-Difluoro-3-(propane-1-sulfonylamino)-benzoyl]-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid pyridin-3-ylamide P-1801 is prepared in one step from 3-[2,6-difluoro-3-(propane-1-sulfonylamino)-benzoyl]-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid 41 and pyridin-3-ylamine 42 as shown in Scheme 6.

Sources & evidence

ORD record: ord-fb9208719ca34990ac1e39594bcbf9dd
Source dataset: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09440969B2

Reaction notes

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