HCID 43167782, compound → HCID 86592113, compound

HRID 601120Notes

Reaction equation

HRID 601120 reaction equation
[CH:1]1([NH:8][C:9]2[N:19]=[CH:18][CH:17]=[CH:16][C:10]=2[C:11]([O:13][CH2:14]C)=[O:12])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(C(CC)CNC1N=CC=CC=1C(OCC)=[O:28])C>>[CH:1]1([N:8]2[C:9]3[N:19]=[CH:18][CH:17]=[CH:16][C:10]=3[C:11](=[O:12])[O:13][C:14]2=[O:28])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 43167782HCID 43167782, compoundHCID 67064133Ethyl 2-[(2-ethylbutyl)amino]nicotinate

Product 1

HCID 86592113HCID 86592113, compound

Procedure

The title compound was prepared according to the procedure of Example 3B substituting the product of Example 71A for the product of Example 3A (0.205 g, 55%). MS (ESI+) m/z 249.1 (M+H)+; 1H NMR (300 MHz, CDCl3) δ 1.63 (m, 6H), 1.84 (m, 4H), 2.43 (m, 2H), 5.39 (s, 1H), 7.24 (dd, J=7.72, 4.78 Hz, 1H), 8.40 (m, 1H), 8.71 (dd, J=4.78, 1.84 Hz, 1H).

Sources & evidence

ORD record
ord-5dc2a01c624c4212b37ce443be261898
Source dataset
uspto-grants-2011_03
Patent number
US07902203B2

Reaction notes

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