Ammonium Hydroxide → HCID 15864348, compound

HRID 601136Notes

Reaction equation

HRID 601136 reaction equation
[NH2:1][C:2]1[C:7]([S:8](Cl)(=[O:10])=[O:9])=[CH:6][C:5]([CH3:12])=[CH:4][N:3]=1.[OH-].[NH4+:14]>>[NH2:1][C:2]1[C:7]([S:8]([NH2:14])(=[O:10])=[O:9])=[CH:6][C:5]([CH3:12])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 189487872-aMino-5-Methylpyridine-3-sulfonyl chloride

Product 1

HCID 15864348HCID 15864348, compound

Procedure

The product of Example 104A was reacted with concentrated ammonium hydroxide at ambient temperature overnight. The reaction mixture was concentrated to give the title compound as a light yellow solid in quantitative yield. MS (DCI/NH3) m/z 188 (M+H)+. 1H NMR (300 MHz, DMSO-d6) δ 2.17 (m, 3H), 6.28 (s, 2H), 7.43 (s, 2H), 7.70 (d, J=1.84 Hz, 1H), 8.00 (d, J=2.21 Hz, 1H).

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-1509d5ad77c547238f72ebc85086f684
Source dataset
uspto-grants-2011_03
Patent number
US07902203B2

Reaction notes

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