Ethyl 2-aminocyclohex-1-ene-1-carboxylate → 5,6,7,8-tetrahydro-2H-3,1-benzoxazine-2,4(1H)-dione

HRID 601141Notes

Reaction equation

HRID 601141 reaction equation
[NH2:1][C:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C:3]=1[C:8]([O:10][CH2:11]C)=[O:9].C(C(CC)CNC1N=CC=CC=1C(OCC)=[O:21])C>>[NH:1]1[C:2]2[CH2:7][CH2:6][CH2:5][CH2:4][C:3]=2[C:8](=[O:9])[O:10][C:11]1=[O:21]

Participants

3

Reactant 2

HCID 312929Ethyl 2-aminocyclohex-1-ene-1-carboxylateHCID 67064133Ethyl 2-[(2-ethylbutyl)amino]nicotinate

Product 1

HCID 138096505,6,7,8-tetrahydro-2H-3,1-benzoxazine-2,4(1H)-dione

Procedure

The title compound was prepared according to the procedure of Example 3B substituting ethyl 2-aminocyclohex-1-ene-1-carboxylate for the product of Example 3A (0.960 g, 97%). MS (ESI−) m/z 166 (M−H)+.

Sources & evidence

ORD record
ord-be9104209980441490f19aced8f83fa6
Source dataset
uspto-grants-2011_03
Patent number
US07902203B2

Reaction notes

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